Industrial Applications of Crystallography

The Pharmaceutical Industry

The uses of XRD in the Pharmaceutical Industry Include:

• Small molecule single-crystal XRD to determine molecular structure and absolute stereochemistry
• Powder XRD to study polymorphism and solid-state stability
• Macromolecular crystallography to determine three-dimensional structures of biological targets and target-inhibitor complexes

Examples

A State-of-the-Art CCD Diffractometer which is used for rapid data collection on both small and macromolecular crystals

Single crystal X-ray structure of the monoclinc form of paracetamol

Structure of Type A Neuraminidase enzyme target with a small molecule inhibitor bound at the active site